Structure via PubChem · Public domain (PubChem)
gamendazole
Sign in to saveAlso known as trans-3-(1-benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid
Gamendazole is a drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). It has been shown to reduce fertility in male rats without affecting testosterone levels, but human clinical trials have not been started.
In the Vinony graph
Vinony's link graph records 3 inbound references to gamendazole, and connects out to pathology, digital object identifier and chemical formula.
It is catalogued under topics including Carboxylic acids, Chembox image size set and Chemical articles with multiple CAS registry numbers.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C18H11Cl2F3N2O2
- Molecular weight
- 415.2 g/mol
- IUPAC name
- (E)-3-[1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)indazol-3-yl]prop-2-enoic acid
- SMILES
- C1=CC2=C(C=C1C(F)(F)F)N(N=C2/C=C/C(=O)O)CC3=C(C=C(C=C3)Cl)Cl
- InChIKey
- KYYQMVUKYQCSQY-AATRIKPKSA-N
- XLogP
- 5.3
- Polar surface area
- 55.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 414.014968
Show 4 more facts
- chemical formula
- C₁₈H₁₁Cl₂F₃N₂O₂
- Commons category
- Gamendazole
- canonical SMILES
- C1=CC2=C(C=C1C(F)(F)F)N(N=C2C=CC(=O)O)CC3=C(C=C(C=C3)Cl)Cl
- isomeric SMILES
- C1=CC2=C(C=C1C(F)(F)F)N(N=C2/C=C/C(=O)O)CC3=C(C=C(C=C3)Cl)Cl
Sources (1)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Rat studies
- References
{{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 442713318 | ImageFile = Gamendazole.svg | ImageClass = skin-invert-image | ImageFile2 = Gamendazole ball-and-stick model.png | ImageClass2 = bg-transparent | ImageSize = 200px | ImageAlt = | PIN = (2E)-3-{1-[(2,4-Dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl}prop-2-enoic acid | OtherNames = trans-3-(1-Benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid) |Section1= |Section2= |Section3= }}
Gamendazole is a drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). It has been shown to reduce fertility in male rats without affecting testosterone levels, but human clinical trials have not been started.
Excerpted from Wikipedia’s “gamendazole” article, available under the CC BY-SA 4.0 licence.