Structure via PubChem · Public domain (PubChem)
gliclazide
Sign in to saveAlso known as 1-(3-azabicyclo[3.3.0]oct-3-yl)-3-(p-tolylsulfonyl)urea, 1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea, N-(4-methylbenzenesulfonyl)-N'-(3-azabicyclo[3.3.0]oct-3-yl)urea
Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth.
Chemical data
- Formula
- C15H21N3O3S
- Molecular weight
- 323.4 g/mol
- IUPAC name
- 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
- SMILES
- CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
- InChIKey
- BOVGTQGAOIONJV-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 86.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1,662 papers- Gliclazide.Profiles of drug substances, excipients, and related methodology · 2017
- Evaluating gliclazide for the treatment of type 2 diabetes mellitus.Expert opinion on pharmacotherapy · 2022
- Gliclazide modified release.Drugs · 2002
- Is gliclazide a sulfonylurea with difference? A review in 2016.Expert review of clinical pharmacology · 2016
- Gliclazide.Acta crystallographica. Section C, Crystal structure communications · 1999
via PubMed
Wikidata facts
- Mass
- 323.13
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₅H₂₁N₃O₃S
- canonical SMILES
- CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
- Commons category
- Gliclazide
- defined daily dose
- 60
- subject has role
- essential medicine
Sources (6)
via Wikidata · CC0
~5 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Interactions
- Overdose
- Mechanism of action
- Properties
- Metabolism
- References
Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth.
Side effect may include low blood sugar, vomiting, abdominal pain, rash, and liver problems. Use by those with significant kidney problems or liver problems or who are pregnant is not recommended. Gliclazide is in the sulfonylurea family of medications. It works mostly by increasing the release of insulin.
Excerpted from Wikipedia’s “gliclazide” article, available under the CC BY-SA 4.0 licence.