Structure via PubChem · Public domain (PubChem)
guanabenz
Sign in to saveAlso known as GBZ, NSC 68982, Wy 8678, Wytensin®, Guanabenzo, Guanabenzum
Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist that is selective to the alpha-2 adrenergic receptor. Guanabenz is used as an antihypertensive drug used in the treatment of high blood pressure (hypertension).
In the Vinony graph
Vinony's link graph records 731 inbound references to guanabenz, and connects out to propranolol, atenolol and adrenergic receptor.
Vinony files it under Alpha2-adrenergic agonists, Chloroarenes and Drugboxes which contain changes to watched fields.
Vinony links it to 10 Wikipedia language editions.
Chemical data
- Formula
- C8H8Cl2N4
- Molecular weight
- 231.08 g/mol
- IUPAC name
- 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
via ChEMBL · EBI
Research
686 papers- Guanabenz.2006
- Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension.Drugs · 1983
- Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1.Annals of clinical and translational neurology · 2022
- Guanabenz modulates microglia and macrophages during demyelination.Scientific reports · 2020
- Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization.Current neurovascular research · 2021
via PubMed
Wikidata facts
- Mass
- 230.013
- Has use
- medication
Show 7 more facts
- chemical formula
- C₈H₈Cl₂N₄
- World Health Organisation international non-proprietary name
- guanabenz
- medical condition treated
- arterial hypertension
- isomeric SMILES
- C1=CC(=C(C(=C1)Cl)/C=N/N=C(N)N)Cl
- canonical SMILES
- C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
- subject has role
- antihypertensive drug
- Commons category
- Guanabenz
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Research
- See also
- References
Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist that is selective to the alpha-2 adrenergic receptor. Guanabenz is used as an antihypertensive drug used in the treatment of high blood pressure (hypertension).
The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.
Excerpted from Wikipedia’s “guanabenz” article, available under the CC BY-SA 4.0 licence.
Available in 10 languages
via Wikidata sitelinks · CC0