H2AZ2

Also known as H2A.Z-2, H2AV, H2A histone family member V, H2A.Z variant histone 2, H2AFV

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to H2AZ2, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 7.

Vinony links it to 5 Wikipedia language editions.

Gene data

H2AZ2

Name: H2A.Z variant histone 2
Type: protein-coding
Position: 44,826,791–44,848,146 (−)
Aliases: H2A.Z-2, H2AFV, H2AV
Ensembl: ENSG00000105968
RefSeq RNA: NM_012412.5, NM_138635.3, NM_201436.3, NM_201516.3, NM_201517.3
RefSeq protein: NP_036544.1, NP_619541.1, NP_958844.1, NP_958924.1, NP_958925.1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015].

Gene Ontology

Biological process

chromatin organization heterochromatin formation

Molecular function

DNA binding structural constituent of chromatin structural constituent of chromatin protein heterodimerization activity molecular adaptor activity

Cellular component

nucleosome nucleosome nucleosome nucleus nucleus nucleus nucleus chromosome

Pathways

Necroptosis - Homo sapiens (human)Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine

via MyGene.info

Gene · Ensembl

H2A.Z variant histone 2

Symbol: H2AZ2
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:44,826,791-44,848,146
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein H2AFV PDB 1f66.png

Show 8 more facts

HomoloGene ID: 83271
genomic end: 44887682
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/94239
genomic start: 44866390
chromosome: human chromosome 7
cytogenetic location: 7p13
expressed in: Achilles tendon

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.

Excerpted from Wikipedia’s “H2AZ2” article, available under the CC BY-SA 4.0 licence.