HBA1

Name

hemoglobin subunit alpha 1

Type

protein-coding

Position

176,660–177,527 (+)

Aliases

ECYT7, HBA-T3, HBH, METHBA

Ensembl

ENSG00000206172

RefSeq RNA

NM_000558.5

RefSeq protein

NP_000549.1

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

hemoglobin subunit alpha 1

Symbol

HBA1

Biotype

Protein coding

Organism

Homo sapiens

Location

16:176,660-177,527

Strand

Forward (+)

Assembly

GRCh38