hydroxydione
Sign in to saveAlso known as 21-hydroxy-5β-pregnane-3,20-dione, 5beta-dihydrodeoxycorticosterone, 5β-dihydrodeoxycorticosterone, 21-hydroxy-5beta-pregnane-3,20-dione
Hydroxydione, as hydroxydione sodium succinate (, , ) (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. It was introduced in 1957, and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.
Wikidata facts
- Mass
- 332.235145
Show 3 more facts
- chemical formula
- C₂₁H₃₂O₃
- canonical SMILES
- CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4C(=O)CO)C
- isomeric SMILES
- C[C@]12CCC(=O)C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)C
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2 sectionsContents
- Chemistry
- References
Hydroxydione, as hydroxydione sodium succinate (, , ) (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. It was introduced in 1957, and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.
==Chemistry==