Structure via PubChem · Public domain (PubChem)
ibutilide
Also known as Corvert®, U-70226E, N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide, Ibutilidum, Ibutilid, Ibutilida
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.
Chemical data
- Formula
- C20H36N2O3S
- Molecular weight
- 384.6 g/mol
- IUPAC name
- N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1995
- Admin. routes
- parenteral
- Indications
- cardiac arrhythmia
via ChEMBL · EBI
Research
422 papers- Ibutilide.Circulation · 1998
~5 min read
Article
10 sectionsContents
- Mechanism of action
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Excretion
- Adverse effects and contraindications
- Patient Information
- See also
- References
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| tradename = Corvert | Drugs.com = | MedlinePlus = a601248 | pregnancy_AU = | pregnancy_US = | pregnancy_category = C | legal_AU = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Intravenous