Structure via PubChem · Public domain (PubChem)
ایفوسفامید
Sign in to saveAlso known as Holoxan®, Ifex®, MJF-9325, Z-4942, Iphosphamide, Isofosfamide, isosfamide, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Ifosfamide, sold under the brand name Ifex among others, is a chemotherapy medication used to treat a number of types of cancer. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. It is administered by injection into a vein.
Chemical data
- Formula
- C7H15Cl2N2O2P
- Molecular weight
- 261.08 g/mol
- IUPAC name
- N,3-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
- SMILES
- C1CN(P(=O)(OC1)NCCCl)CCCl
- InChIKey
- HOMGKSMUEGBAAB-UHFFFAOYSA-N
- XLogP
- 0.9
- Polar surface area
- 41.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1988
- Admin. routes
- parenteral
- Indications
- osteosarcoma, neoplasm, sarcoma, neoplasm of mature B-cells
via ChEMBL · EBI
Research
8,347 papers- Ifosfamide-induced nephrotoxicity in oncological patients.Expert review of anticancer therapy · 2024
- Ifosfamide pharmacokinetics.Investigational new drugs · 1991
- Ifosfamide.Journal of the National Cancer Institute · 1988
- Ifosfamide encephalopathy.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2007
- Ifosfamide clinical pharmacokinetics.Clinical pharmacokinetics · 1994
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 260.02971862600003
- Has use
- medication
Show 8 more facts
- chemical formula
- C₇H₁₅Cl₂N₂O₂P
- medical condition treated
- Ewing sarcoma
- World Health Organisation international non-proprietary name
- ifosfamide
- canonical SMILES
- C1CN(P(=O)(OC1)NCCCl)CCCl
- Commons category
- Ifosfamide
- legal status (medicine)
- boxed warning
- isomeric SMILES
- OCC1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
- found in taxon
- Caenorhabditis elegans
Sources (8)
via Wikidata · CC0