IKZF2

Also known as ANF1A2, HELIOS, ZNF1A2, ZNFN1A2, IKAROS family zinc finger 2

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. This protein is a member of Ikaros family of transcription factors.

Gene data

IKZF2

Name: IKAROS family zinc finger 2
Type: protein-coding
Aliases: ANF1A2, HELIOS, ICHAD, IMDIA, ZNF1A2, ZNFN1A2

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

IKAROS family zinc finger 2

Symbol: IKZF2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:212,999,691-213,152,427
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 22659
exact match: identifiers.org/ncbigene/22807
genomic start: 213864429
genomic end: 214017151
cytogenetic location: 2q34

Sources (3)

via Wikidata · CC0

~7 min read

Article

10 sections

Contents

Structure
Function
As transcription factor
As a tumor suppressor
In immune cells
Tregs
In other immune cells
References
Further reading
External links

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. This protein is a member of Ikaros family of transcription factors.

This gene encodes a member of the Ikaros family of zinc-finger proteins. This family of transcription factors consists of five members: Ikaros (Ikzf1), Helios (Ikzf2), Aiolos (Ikzf3), Eos (Ikzf4), and Pegasus (Ikzf5). The Ikaros family members are involved in the hematopoietic development, some to a greater extent than others with Ikaros being expressed in all hematopoietic cells. This protein forms homo- or hetero-dimers with other Ikaros family members. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological relevance of some variants has not been determined.