ING3
Sign in to saveAlso known as Eaf4, ING2, MEAF4, p47ING3, inhibitor of growth family member 3
Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to ING3, and connects out to PubMed, tumor protein p53 and human chromosome 7.
It is catalogued under the topic Genes on human chromosome 7.
Vinony links it to 9 Wikipedia language editions.
Gene data
ING3- Name
- inhibitor of growth family member 3
- Type
- protein-coding
- Position
- 120,950,718–120,977,216 (+)
- Aliases
- Eaf4, MEAF4, p47ING3
- Ensembl
- ENSG00000071243
- RefSeq RNA
- NM_019071.3, NM_198266.1, NM_198267.2, XM_017012369.3, XM_047420535.1
- RefSeq protein
- NP_061944.2, NP_938008.1, XP_016867858.1, XP_047276491.1, XP_054214486.1
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
inhibitor of growth family member 3
- Symbol
- ING3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:120,950,718-120,977,216
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ING3 PDB 1x4i.png
Show 7 more facts
- HomoloGene ID
- 6804
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/54556
- genomic end
- 120617270
- genomic start
- 120950763
- chromosome
- human chromosome 7
- cytogenetic location
- 7q31.31
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Excerpted from Wikipedia’s “ING3” article, available under the CC BY-SA 4.0 licence.