Structure via PubChem · Public domain (PubChem)
istradefylline
Sign in to saveIstradefylline, sold under the brand name Nourianz, is a medication used as an add-on treatment to levodopa/carbidopa in adults with Parkinson's disease (PD) experiencing "off" episodes. Istradefylline reduces "off" periods resulting from long-term treatment with the antiparkinson drug levodopa. An "off" episode is a time when a patient's medications are not working well, causing an increase in PD symptoms, such as tremor and difficulty walking.
Key facts
- Drug.verifiedrevid
- 443805396
- Drug.image
- Istradefylline structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.image2
- ISTRADEFYLLINE BALLANDSTICK-3D.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Nouriast, Nourianz
- Drug.DailyMedID
- Istradefylline
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N04
- Drug.ATC_suffix
- CX01
- Drug.legal_US
- Rx-only
- Drug.protein_bound
- 98%
- Drug.metabolism
- Mainly CYP1A1, CYP3A4, and CYP3A5
- Drug.elimination_half life
- 64–69 hrs
- Drug.excretion
- 68% faeces, 18% urine
- Drug.CAS_number
- 155270-99-8
- Drug.PubChem
- 5311037
via Wikipedia infobox
Chemical data
- Formula
- C20H24N4O4
- Molecular weight
- 384.4 g/mol
- IUPAC name
- 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Admin. routes
- oral
- Indications
- liver disease, drug dependence, amyotrophic lateral sclerosis, Parkinson disease
via ChEMBL · EBI
Research
391 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 384.179755
Show 5 more facts
- chemical formula
- C₂₀H₂₄N₄O₄
- isomeric SMILES
- CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
- canonical SMILES
- CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C
- medical condition treated
- Parkinson's disease
- Commons category
- Istradefylline
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Adverse effects
- Mechanism of action
- History
- Research
- Wakefulness effects
- Motivational disorders
- Other conditions
- See also
- References
- External links
Istradefylline, sold under the brand name Nourianz, is a medication used as an add-on treatment to levodopa/carbidopa in adults with Parkinson's disease (PD) experiencing "off" episodes. Istradefylline reduces "off" periods resulting from long-term treatment with the antiparkinson drug levodopa. An "off" episode is a time when a patient's medications are not working well, causing an increase in PD symptoms, such as tremor and difficulty walking.
Relatively common side effects include involuntary muscle movements (dyskinesia), constipation, hallucinations, dizziness, and, much like its parent molecule caffeine, nausea and sleeplessness.
Excerpted from Wikipedia’s “istradefylline” article, available under the CC BY-SA 4.0 licence.