macitentan

Also known as ACT-064992, ACT064992, ACT 064992

composé chimique

In the Vinony graph

Within Vinony's link graph, macitentan is referenced by 159 other articles, and connects out to digital object identifier, chemical formula and integral.

It sits within the topics 4-Bromophenyl compounds, Bromoarenes and Drugs developed by Johnson & Johnson.

Its subject is documented across 11 Wikipedia language editions.

Chemical data

Formula: C19H20Br2N6O4S
Molecular weight: 588.3 g/mol
IUPAC name: 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
SMILES: CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
InChIKey: JGCMEBMXRHSZKX-UHFFFAOYSA-N
XLogP: 3.7
Polar surface area: 137 Å²
H-bond donors: 2
H-bond acceptors: 10
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2010
Admin. routes: oral
Indications: pulmonary arterial hypertension, idiopathic pulmonary fibrosis, systemic scleroderma, glioblastoma multiforme

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 585.9633483200003
Has use: medication

Show 7 more facts

chemical formula: C₁₉H₂₀Br₂N₆O₄S
canonical SMILES: CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
World Health Organisation international non-proprietary name: macitentan
defined daily dose: 10
medical condition treated: pulmonary hypertension
Commons category: Macitentan
legal status (medicine): boxed warning

Sources (7)

via Wikidata · CC0

Article · Français

Le macitentan est un inhibiteur des récepteurs de l'endothéline utilisée comme traitement de l'hypertension artérielle pulmonaire. Il s'agit d'une modification du bosentan, autre médicament de la même classe.

Abstract from DBpedia / Wikipedia · CC BY-SA