ADGRA1

Also known as GPR123, adhesion G protein-coupled receptor A1

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Gene data

ADGRA1

Name: adhesion G protein-coupled receptor A1
Type: protein-coding
Position: 133,087,924–133,131,675 (+)
Aliases: GPR123
Ensembl: ENSG00000197177
RefSeq RNA: NM_001083909.3, NM_001291085.2, NM_032422.2, XM_011540273.1, XM_017016779.2
RefSeq protein: NP_001077378.1, NP_001278014.1, XP_011538575.1, XP_016872268.1, XP_054222921.1

This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014].