MCF2L

Name

MCF.2 cell line derived transforming sequence like

Type

protein-coding

Position

112,894,378–113,099,742 (+)

Aliases

ARHGEF14, DBS, OST

Ensembl

ENSG00000126217

RefSeq RNA

NM_001112732.3, NM_001320815.2, NM_001320816.2, NM_001320817.2, NM_001366644.2

RefSeq protein

NP_001106203.2, NP_001307744.1, NP_001307745.1, NP_001307746.1, NP_001353573.1

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].