Structure via PubChem · Public domain (PubChem)
melitracen
Sign in to saveMelitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containing both melitracen and flupentixol.
Chemical data
- Formula
- C21H25N
- Molecular weight
- 291.4 g/mol
- IUPAC name
- 3-(10,10-dimethylanthracen-9-ylidene)-N,N-dimethylpropan-1-amine
- SMILES
- CC1(C2=CC=CC=C2C(=CCCN(C)C)C3=CC=CC=C31)C
- InChIKey
- GWWLWDURRGNSRS-UHFFFAOYSA-N
- XLogP
- 5.6
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Research
128 papers- Melitracen and flupentixol (deanxit) use disorder in Lebanon.Heliyon · 2023
- Flupentixol/melitracen for chronic refractory cough after treatment failure with other neuromodulators.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
- Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trial.EClinicalMedicine · 2025
- The Efficacy of Flupentixol-Melitracen in the Adjuvant Therapy of Ulcerative Colitis in the Chinese Population: A Meta-Analysis.Gastroenterology research and practice · 2019
- Case report: Extrapontine myelinolysis combined with flupentixol- and melitracen-induced dysphagia.Frontiers in pharmacology · 2023
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 291.199
Show 6 more facts
- subject has role
- tricyclic antidepressant
- chemical formula
- C₂₁H₂₅N
- canonical SMILES
- CC1(C2=CC=CC=C2C(=CCCN(C)C)C3=CC=CC=C31)C
- medical condition treated
- anxiety disorder
- Commons category
- Melitracen
- defined daily dose
- 75
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containing both melitracen and flupentixol.
The pharmacology of melitracen has not been properly investigated and is largely unknown, but it is likely to act in a similar manner to other TCAs. Indeed, melitracen is reported to have imipramine and amitriptyline-like effects and efficacy against depression and anxiety, though with improved tolerability and a somewhat faster onset of action.
Excerpted from Wikipedia’s “melitracen” article, available under the CC BY-SA 4.0 licence.
Available in 10 languages
via Wikidata sitelinks · CC0