Structure via PubChem · Public domain (PubChem)
mequinol
Sign in to saveAlso known as 4-hydroxyanisole, BMS-181158, Leucobasal®, Leucodine B, p-hydroxyanisole, p-Guaiacol, 4-Methoxyphenol
Mequinol, MeHQ or 4-methoxyphenol, is an organic compound with the formula . It is a phenol with a methoxy group in the para position. A colorless solid, it is used in dermatology and organic chemistry.
Chemical data
- Formula
- C7H8O2
- Molecular weight
- 124.14 g/mol
- IUPAC name
- 4-methoxyphenol
- SMILES
- COC1=CC=C(C=C1)O
- InChIKey
- NWVVVBRKAWDGAB-UHFFFAOYSA-N
- XLogP
- 1.3
- Polar surface area
- 29.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1999
- Admin. routes
- topical
via ChEMBL · EBI
Research
154 papers- Treatment of Solar Lentigines: A Systematic Review of Clinical Trials.Journal of cosmetic dermatology · 2025
- Mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men: a case series and review of the literature.Cutis · 2008
- Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color.The Journal of clinical and aesthetic dermatology · 2010
- Mequinol 2%/tretinoin 0.01% solution: an effective and safe alternative to hydroquinone 3% in the treatment of solar lentigines.Cutis · 2004
- The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies.Journal of the American Academy of Dermatology · 2000
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 124.052
- Has use
- medication
Show 13 more facts
- melting point
- 56
- chemical formula
- C₇H₈O₂
- boiling point
- 469
- canonical SMILES
- COC1=CC=C(C=C1)O
- NIOSH Pocket Guide ID
- 0390
- density
- 1.55
- flash point
- 270
- solubility
- 4
- ionization energy
- 7.5
- vapor pressure
- 0.01
- time-weighted average exposure limit
- 5
- subject has role
- antioxidant
- Commons category
- 4-Methoxyphenol
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Use in dermatology
- Organic chemistry
- Safety
- See also
- References
- External links
Mequinol, MeHQ or 4-methoxyphenol, is an organic compound with the formula . It is a phenol with a methoxy group in the para position. A colorless solid, it is used in dermatology and organic chemistry.
==Use in dermatology== Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass. Dermatologists commonly prescribe the drug to treat liver spots.
Excerpted from Wikipedia’s “mequinol” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0