microRNA
Sign in to savethumb|400px|Pre-miRNA instead of Pri-miRNA in the first point of mechanism. Diagram of microRNA (miRNA) action with mRNA thumb|400px|Examples of miRNA hairpins (stem-loops), with the mature miRNAs shown in red
Article
37 sectionsContents
- History
- Nomenclature
- Targets
- Biogenesis
- Transcription
- Nuclear processing
- Nuclear export
- Cytoplasmic processing
- Biogenesis in plants
- RNA-induced silencing complex
- Mode of silencing and regulatory loops
- Turnover
- Cellular functions
- Evolution
- Experimental detection and manipulation
- Human and animal diseases
- Inherited diseases
- Cancer
- DNA repair and cancer
- Heart disease
- miRNA-712
- Origin
- Mechanism
- Human homolog microRNA-205
- Kidney disease
- Nervous system
- Stroke
- Alcoholism
- Obesity
- Hemostasis
- Plants
- Viruses
- Target prediction
- See also
- References
- Further reading
- External links
thumb|400px|Pre-miRNA instead of Pri-miRNA in the first point of mechanism. Diagram of microRNA (miRNA) action with mRNA thumb|400px|Examples of miRNA hairpins (stem-loops), with the mature miRNAs shown in red
Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals, and even some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in messenger RNA (mRNA) molecules, then silence said mRNA molecules by one or more of the following processes: Cleaving the mRNA strand into two pieces. Destabilizing the mRNA by shortening its poly(A) tail. Reducing translation of the mRNA into proteins.