Structure via PubChem · Public domain (PubChem)
milameline
Sign in to saveMilameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued.
Chemical data
- Formula
- C8H14N2O
- Molecular weight
- 154.21 g/mol
- IUPAC name
- (E)-N-methoxy-1-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)methanimine
- SMILES
- CN1CCC=C(C1)/C=N/OC
- InChIKey
- YMMXHEYLRHNXAB-RMKNXTFCSA-N
- XLogP
- 0.7
- Polar surface area
- 24.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 154.110613
Show 4 more facts
- chemical formula
- C₈H₁₄N₂O
- isomeric SMILES
- CN1CCC=C(C1)/C=N/OC
- canonical SMILES
- CN1CCC=C(C1)C=NOC
- Commons category
- Milameline
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued. Changing the O-methyl aldoxime to an O-propargyl oxime instead gives a separate molecule called RU 35986.
== See also == Alvameline Sabcomeline Tazomeline Xanomeline
Excerpted from Wikipedia’s “milameline” article, available under the CC BY-SA 4.0 licence.