MTAP
Sign in to saveAlso known as BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus, methylthioadenosine phosphorylase
'''S-methyl-5'-thioadenosine phosphorylase (MTAP)''' is an enzyme responsible for polyamine metabolism. In humans, it is encoded by the methylthioadenosine phosphorylase (MTAP) gene on chromosome 9. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
Gene data
MTAP- Name
- methylthioadenosine phosphorylase
- Type
- protein-coding
- Aliases
- BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021].
via MyGene.info
Wikidata facts
- Image
- Protein MTAP PDB 1cb0.png
Show 5 more facts
- HomoloGene ID
- 1838
- exact match
- identifiers.org/ncbigene/4507
- genomic end
- 21931646
- genomic start
- 21802636
- cytogenetic location
- 9p21.3
Sources (4)
via Wikidata · CC0
~7 min read
Article
8 sectionsContents
- Classification
- Gene
- Structure
- Function
- Cancer
- References
- Further reading
- External links
'''S-methyl-5'-thioadenosine phosphorylase (MTAP)' is an enzyme responsible for polyamine metabolism. In humans, it is encoded by the methylthioadenosine phosphorylase (MTAP) gene on chromosome 9. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. It is responsible for the first step in this pathway, where it catalyzes the reversible phosphorylation of MTA to adenine and 5-methylthioribose-1-phosphate. This takes place after MTA is generated from S-adenosylmethionine.