NEFM
Sign in to saveAlso known as NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium, neurofilament medium chain
Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.
Gene data
NEFM- Name
- neurofilament medium chain
- Type
- protein-coding
- Position
- 24,913,758–24,919,098 (+)
- Aliases
- NEF3, NF-M, NFM
- Ensembl
- ENSG00000104722
- RefSeq RNA
- NM_001105541.2, NM_005382.2
- RefSeq protein
- NP_001099011.1, NP_005373.2
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
neurofilament medium chain
- Symbol
- NEFM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:24,913,758-24,919,098
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 38041
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4741
- genomic end
- 24776607
- genomic start
- 24913758
- chromosome
- human chromosome 8
- cytogenetic location
- 8p21.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.
== Function ==
Excerpted from Wikipedia’s “NEFM” article, available under the CC BY-SA 4.0 licence.