Structure via PubChem · Public domain (PubChem)
nifenazone
Sign in to saveNifenazone is a drug that has been used as an analgesic for a number of rheumatic conditions.
Chemical data
- Formula
- C17H16N4O2
- Molecular weight
- 308.33 g/mol
- IUPAC name
- N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)pyridine-3-carboxamide
- SMILES
- CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)C3=CN=CC=C3
- InChIKey
- BRZANEXCSZCZCI-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 65.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Myalgia, Arthralgia, pain, Fever
via ChEMBL · EBI
Research
10 papers- TRIAL OF NIFENAZONE ("THYLIN").British medical journal · 1964
- The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin.Nature cell biology · 2020
- [Nifenazone, biotransformation in humans].Archiv der Pharmazie · 1985
- Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity.ChemMedChem · 2020
- The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study.Physical chemistry chemical physics : PCCP · 2014
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 308.127
Show 3 more facts
- canonical SMILES
- CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)C3=CN=CC=C3
- chemical formula
- C₁₇H₁₆N₄O₂
- subject has role
- non-steroidal anti-inflammatory drug
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Nifenazone is a drug that has been used as an analgesic for a number of rheumatic conditions.
==Synthesis== class=skin-invert-image|upright=2 Nifenazone is the amide formed when ampyrone and the acid chloride of nicotinic acid are combined in a Schotten–Baumann reaction.
Excerpted from Wikipedia’s “nifenazone” article, available under the CC BY-SA 4.0 licence.
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