nitrendipine

Also known as BAY e 5009, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary (essential) hypertension to decrease blood pressure and can reduce the cardiotoxicity of cocaine.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 408771000
Drug.IUPAC_name: (RS)-3-Ethyl 5-methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Drug.image: (RS)-Nitrendipin Structural Formula V1.svg
Drug.image_class: skin-invert-image
Drug.alt: Skeletal formula of nitrendipine
Drug.width: 200
Drug.image2: Nitrendipine-3D-balls.png
Drug.image_class2: bg-transparent
Drug.alt2: Ball-and-stick model of the nitrendipine molecule
Drug.chirality: Racemic mixture
Drug.tradename: Baypress
Drug.routes_of_administration: By mouth
Drug.bioavailability: 60–70%
Drug.protein_bound: 98%
Drug.metabolism: Hepatic (completely)
Drug.onset: 1–2 hours

via Wikipedia infobox

Research

3,205 papers

Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.Drugs · 1987
Nitrendipine: a new dihydropyridine calcium-channel antagonist for the treatment of hypertension.DICP : the annals of pharmacotherapy · 1990
Nitrendipine and metabolic balance.Journal of cardiovascular pharmacology · 1991
Fixed-dose combination enalapril/nitrendipine: a review of its use in mild-to-moderate hypertension.Drugs · 2004
Nitrendipine/digoxin interaction.Journal of cardiovascular pharmacology · 1987

via PubMed

Wikidata facts

Mass: 360.132136

Show 6 more facts

chemical formula: C₁₈H₂₀N₂O₆
canonical SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C
World Health Organisation international non-proprietary name: nitrendipine
defined daily dose: 20
MCN code: 2933.39.44
Commons category: Nitrendipine

Sources (4)

via Wikidata · CC0

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Article

4 sections

Contents

Medical uses
Mechanism of action
Stereochemistry
References

Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary (essential) hypertension to decrease blood pressure and can reduce the cardiotoxicity of cocaine.

It was patented in 1971 and approved for medical use in 1985.