-Nitrendipin%20Structural%20Formula%20V1.svg)
nitrendipine
Sign in to saveAlso known as BAY e 5009, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary (essential) hypertension to decrease blood pressure and can reduce the cardiotoxicity of cocaine.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 408771000
- Drug.IUPAC_name
- (RS)-3-Ethyl 5-methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Drug.image
- (RS)-Nitrendipin Structural Formula V1.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of nitrendipine
- Drug.width
- 200
- Drug.image2
- Nitrendipine-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the nitrendipine molecule
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Baypress
- Drug.routes_of_administration
- By mouth
- Drug.bioavailability
- 60–70%
- Drug.protein_bound
- 98%
- Drug.metabolism
- Hepatic (completely)
- Drug.onset
- 1–2 hours
via Wikipedia infobox
Research
3,205 papers- Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.Drugs · 1987
- Nitrendipine: a new dihydropyridine calcium-channel antagonist for the treatment of hypertension.DICP : the annals of pharmacotherapy · 1990
- Nitrendipine and metabolic balance.Journal of cardiovascular pharmacology · 1991
- Fixed-dose combination enalapril/nitrendipine: a review of its use in mild-to-moderate hypertension.Drugs · 2004
- Nitrendipine/digoxin interaction.Journal of cardiovascular pharmacology · 1987
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 360.132136
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₈H₂₀N₂O₆
- canonical SMILES
- CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C
- World Health Organisation international non-proprietary name
- nitrendipine
- defined daily dose
- 20
- subject has role
- calcium channel blocker
- MCN code
- 2933.39.44
- Commons category
- Nitrendipine
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Medical uses
- Mechanism of action
- Stereochemistry
- References
Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary (essential) hypertension to decrease blood pressure and can reduce the cardiotoxicity of cocaine.
It was patented in 1971 and approved for medical use in 1985.
Excerpted from Wikipedia’s “nitrendipine” article, available under the CC BY-SA 4.0 licence.