Structure via PubChem · Public domain (PubChem)
oltipraz
Sign in to saveAlso known as 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione, RP 35972, 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione, RP-35,972
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radicals, which can be toxic.
In the Vinony graph
Within Vinony's link graph, oltipraz is referenced by 6 other articles, and connects out to medication, Rodentia and digital object identifier.
Vinony files it under Antineoplastic drugs, Antiparasitic agents and Chemical pages without DrugBank identifier.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C8H6N2S3
- Molecular weight
- 226.3 g/mol
- IUPAC name
- 4-methyl-5-pyrazin-2-yldithiole-3-thione
- SMILES
- CC1=C(SSC1=S)C2=NC=CN=C2
- InChIKey
- CKNAQFVBEHDJQV-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 108 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- non-alcoholic fatty liver disease, cirrhosis of liver, lung cancer
via ChEMBL · EBI
Research
526 papers- Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication.Journal of cellular biochemistry. Supplement · 1995
- Oltipraz: a laboratory and clinical review.Journal of cellular biochemistry. Supplement · 1993
- Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.Journal of cellular biochemistry. Supplement · 1997
- Oltipraz: clinical opportunities for cancer chemoprevention. p.Journal of cellular biochemistry. Supplement · 1995
- Chemopreventive activity of oltipraz.Pharmacology & therapeutics · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 225.969
Show 4 more facts
- chemical formula
- C₈H₆N₂S₃
- canonical SMILES
- CC1=C(SSC1=S)C2=NC=CN=C2
- World Health Organisation international non-proprietary name
- oltipraz
- Commons category
- Oltipraz
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radicals, which can be toxic.
== References ==
Excerpted from Wikipedia’s “oltipraz” article, available under the CC BY-SA 4.0 licence.