oltipraz
Sign in to saveAlso known as 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione, RP 35972, 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione, RP-35,972
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radicals, which can be toxic.
Research
526 papers- Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication.Journal of cellular biochemistry. Supplement · 1995
- Oltipraz: a laboratory and clinical review.Journal of cellular biochemistry. Supplement · 1993
- Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.Journal of cellular biochemistry. Supplement · 1997
- Oltipraz: clinical opportunities for cancer chemoprevention. p.Journal of cellular biochemistry. Supplement · 1995
- Chemopreventive activity of oltipraz.Pharmacology & therapeutics · 1998
via PubMed
Wikidata facts
- Mass
- 225.969
Show 4 more facts
- chemical formula
- C₈H₆N₂S₃
- canonical SMILES
- CC1=C(SSC1=S)C2=NC=CN=C2
- World Health Organisation international non-proprietary name
- oltipraz
- Commons category
- Oltipraz
Sources (2)
via Wikidata · CC0
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Article
1 sectionsContents
- References
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radicals, which can be toxic.
== References ==