osemozotan
Sign in to saveAlso known as MKC-242
Osemozotan (MKC-242) is a selective 5-HT1A receptor agonist with some functional selectivity, acting as a full agonist at presynaptic and a partial agonist at postsynaptic 5-HT1A receptors. 5-HT1A receptor stimulation influences the release of various neurotransmitters including serotonin, dopamine, norepinephrine, and acetylcholine. 5-HT1A receptors are inhibitory G protein-coupled receptor.
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 379.11865048399994
Show 4 more facts
- chemical formula
- C₁₉H₂₂ClNO₅
- canonical SMILES
- C1C(OC2=CC=CC=C2O1)CNCCCOC3=CC4=C(C=C3)OCO4.Cl
- Commons category
- Osemozotan
- isomeric SMILES
- Cl.c1ccc2c(c1)OC[C@H](CNCCCOc1ccc3c(c1)OCO3)O2
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
11 sectionsContents
- Pharmacodynamics
- Pharmacokinetics
- Uses
- Pain
- Aggressive behavior
- Anxiety and depression
- Obsessive-compulsive disorder
- Drug dependence
- Prevalence of mental disease states
- See also
- References
Osemozotan (MKC-242) is a selective 5-HT1A receptor agonist with some functional selectivity, acting as a full agonist at presynaptic and a partial agonist at postsynaptic 5-HT1A receptors. 5-HT1A receptor stimulation influences the release of various neurotransmitters including serotonin, dopamine, norepinephrine, and acetylcholine. 5-HT1A receptors are inhibitory G protein-coupled receptor.
Osemozotan has been shown in animal studies to have antidepressant, anxiolytic, antiobsessional, serenic, and analgesic effects. It is used to investigate the role of 5-HT1A receptors in modulating the release of dopamine and serotonin in the brain and their involvement in addiction to stimulants such as cocaine and methamphetamine.
Excerpted from Wikipedia’s “osemozotan” article, available under the CC BY-SA 4.0 licence.