پارکوکسیب

Also known as Parecoxib

Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved in the European Union for short term perioperative pain control.

Chemical data

Formula: C19H18N2O4S
Molecular weight: 370.4 g/mol
IUPAC name: N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide
SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
InChIKey: TZRHLKRLEZJVIJ-UHFFFAOYSA-N
XLogP: 3.3
Polar surface area: 97.7 Å²
H-bond donors: 1
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2002
Indications: rheumatic disease, pain, renal colic, Shoulder pain

via ChEMBL · EBI

Research

769 papers

Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial.Gut · 2025
Parecoxib: a shift in pain management?Expert review of neurotherapeutics · 2004
Intravenous parecoxib for early postoperative cognitive dysfunction in elderly patients: evidence from a meta-analysis.Expert review of clinical pharmacology · 2020
Efficacy of parecoxib sodium on postoperative shivering: meta-analysis of clinical trials.The Journal of international medical research · 2018
Parecoxib (parecoxib sodium).Drugs · 2001

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 370.099
Has use: medication

Show 6 more facts

significant drug interaction: tacrolimus
chemical formula: C₁₉H₁₈N₂O₄S
canonical SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
defined daily dose: 40
subject has role: COX-2 inhibitor
Commons category: Parecoxib

Sources (6)

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via Wikidata sitelinks · CC0