Structure via PubChem · Public domain (PubChem)
parecoxib
Sign in to saveParecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved in the European Union for short term perioperative pain control.
Chemical data
- Formula
- C19H18N2O4S
- Molecular weight
- 370.4 g/mol
- IUPAC name
- N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide
- SMILES
- CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
- InChIKey
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 97.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2002
- Indications
- rheumatic disease, pain, renal colic, Shoulder pain
via ChEMBL · EBI
Research
769 papers- Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial.Gut · 2025
- Parecoxib: a shift in pain management?Expert review of neurotherapeutics · 2004
- Intravenous parecoxib for early postoperative cognitive dysfunction in elderly patients: evidence from a meta-analysis.Expert review of clinical pharmacology · 2020
- Efficacy of parecoxib sodium on postoperative shivering: meta-analysis of clinical trials.The Journal of international medical research · 2018
- Parecoxib (parecoxib sodium).Drugs · 2001
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 370.099
- Has use
- medication
Show 6 more facts
- significant drug interaction
- tacrolimus
- chemical formula
- C₁₉H₁₈N₂O₄S
- canonical SMILES
- CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
- defined daily dose
- 40
- subject has role
- COX-2 inhibitor
- Commons category
- Parecoxib
Sources (6)
via Wikidata · CC0
~4 min read
Encyclopedic overview
3 sectionsContents
- Approval
- References
- Further reading
{{Drugbox | Verifiedfields = changed | verifiedrevid = 464197422 | image = Parecoxib.svg | image_class = skin-invert-image
| pronounce = | tradename = | Drugs.com = | MedlinePlus = | DailyMedID = | pregnancy_AU = C | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = Intravenous, intramuscular | class = | ATC_prefix = M01 | ATC_suffix = AH04 | ATC_supplemental =
Excerpted from Wikipedia’s “parecoxib” article, available under the CC BY-SA 4.0 licence.
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