piribedil
Sign in to savePiribedil is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.
Research
593 papersvia PubMed
Wikidata facts
- Mass
- 298.142976
Show 3 more facts
- chemical formula
- C₁₆H₁₈N₄O₂
- canonical SMILES
- C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4
- Commons category
- Piribedil
via Wikidata · CC0
~3 min read
Article
8 sectionsContents
- Medical uses
- Other uses
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- References
Piribedil is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.
==Medical uses== Treatment of Parkinson's disease (PD), either as monotherapy (without levodopa) or in combination with L-DOPA therapy, in the early stages of the disease as well as in the advanced ones Treatment of pathological cognitive deficits in the elderly (impaired attention, motivation, memory, etc.) Treatment of dizziness in the young patients Treatment of retinal ischemic manifestations Adjunctive treatment of intermittent claudication due to peripheral vascular disease (PVD) of the lower limbs (stage 2) Adjunctive treatment of anhedonia, apathy and treatment-resistant depression in unipolar and bipolar depressives (off-label) Treatment of gait disorders associated with Parkinson's disease (no related cause) and other forms of parkinsonism