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prajmaline
Sign in to savePrajmaline (Neo-gilurythmal) is a class Ia antiarrhythmic agent which has been available since the 1970s. Class Ia drugs increase the time one action potential lasts in the heart. Prajmaline is a semi-synthetic propyl derivative of ajmaline, with a higher bioavailability than its predecessor. It acts to stop arrhythmias of the heart through a frequency-dependent block of cardiac sodium channels.
In the Vinony graph
Vinony's link graph records 348 inbound references to prajmaline, and connects out to digital object identifier, chemical formula and molar mass.
It is catalogued under topics including Alkaloids, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C23H33N2O2+
- Molecular weight
- 369.5 g/mol
- IUPAC name
- (1R,9R,10S,13S,14R,16S,18R)-13-ethyl-8-methyl-15-propyl-8-aza-15-azoniahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol
- SMILES
- CCC[N+]12[C@H]3CC([C@@H]([C@H]1O)CC)C4[C@@H]2C[C@@]5([C@H]3N(C6=CC=CC=C65)C)[C@@H]4O
- InChIKey
- UAUHEPXILIZYCU-CVYIOYQLSA-N
- XLogP
- 2.7
- Polar surface area
- 43.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 1
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 369.25365471609
Show 5 more facts
- isomeric SMILES
- CCC[N@@+]12[C@H]3C[C@]45[C@H](O)[C@H]3[C@@H](C[C@H]1[C@@H]4N(C)C6=CC=CC=C56)[C@H](CC)[C@H]2O
- subject has role
- antiarrhythmic agent
- defined daily dose
- 30
- chemical formula
- C₂₃H₃₃N₂O₂⁺
- canonical SMILES
- CCC[N+]12C(O)C(CC)C3CC1C1N(C)c4ccccc4C14CC2C3C4O
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Mechanism
- Uses
- Administration
- Pharmacokinetics
- Side Effects
- Overdose
- Other Potential Uses
- References
Prajmaline (Neo-gilurythmal) is a class Ia antiarrhythmic agent which has been available since the 1970s. Class Ia drugs increase the time one action potential lasts in the heart. Prajmaline is a semi-synthetic propyl derivative of ajmaline, with a higher bioavailability than its predecessor. It acts to stop arrhythmias of the heart through a frequency-dependent block of cardiac sodium channels.
==Mechanism== Prajmaline causes a resting block in the heart. A resting block is the depression of a person's Vmax after a resting period. This effect is seen more in the atrium than the ventricle. The effects of some Class I antiarrhythmics are only seen in a patient who has a normal heart rate (~1 Hz). This is due to the effect of a phenomenon called reverse use dependence. The higher the heart rate, the less effect Prajmaline will have.
Excerpted from Wikipedia’s “prajmaline” article, available under the CC BY-SA 4.0 licence.