RBBP4

Also known as NURF55, RBAP48, lin-53, retinoblastoma binding protein 4, RB binding protein 4, chromatin remodeling factor

Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.

Gene data

RBBP4

Name: RB binding protein 4, chromatin remodeling factor
Type: protein-coding
Aliases: NURF55, RBAP48, lin-53

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

via MyGene.info

Gene · Ensembl

RB binding protein 4, chromatin remodeling factor

Symbol: RBBP4
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:32,651,043-32,705,899
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Research

228 papers

RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.Neuro-oncology · 2022
Rbbp4 Suppresses Premature Differentiation of Embryonic Stem Cells.Stem cell reports · 2021
RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression.G3 (Bethesda, Md.) · 2022
RBBP4 is an epigenetic barrier for the induced transition of pluripotent stem cells into totipotent 2C-like cells.Nucleic acids research · 2023
RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway.World journal of gastroenterology · 2020

via PubMed

Wikidata facts

Image: Protein RBBP4 PDB 2XU7.png

Show 5 more facts

HomoloGene ID: 21153
exact match: identifiers.org/ncbigene/5928
genomic end: 33151812
genomic start: 33116743
cytogenetic location: 1p35.1

Sources (4)

via Wikidata · CC0

~2 min read

Article

5 sections

Contents

Function
Clinical significance
Interactions
References
Further reading

Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.

== Function == This gene encodes a ubiquitously expressed nuclear protein that belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2/NuRD complex that has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of corepressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes.