Structure via PubChem · Public domain (PubChem)
レパグリニド
Sign in to saveAlso known as (-)-repaglinide, AGEE-623ZW, AG-EE 388 ZW, AG-EE 623 ZW
Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is a medication used in addition to diet and exercise for blood sugar control in type 2 diabetes. The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas; like other antidiabetic drugs, a main side effect concern is hypoglycemia. It is sold by Novo Nordisk under the name of Prandin in the United States, Gluconorm in Canada, Surepost in Japan, Repaglinide in Egypt, and Novonorm elsewhere. In Japan it is produced by Dain
Chemical data
- Formula
- C27H36N2O4
- Molecular weight
- 452.6 g/mol
- IUPAC name
- 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid
- SMILES
- CCOC1=C(C=CC(=C1)CC(=O)N[C@@H](CC(C)C)C2=CC=CC=C2N3CCCCC3)C(=O)O
- InChIKey
- FAEKWTJYAYMJKF-QHCPKHFHSA-N
- XLogP
- 5.2
- Polar surface area
- 78.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1997
- Admin. routes
- oral
- Indications
- diabetes mellitus, hypertension, atherosclerosis, Hypercholesterolemia
via ChEMBL · EBI
Research
1,006 papers- Repaglinide.Drugs & aging · 1998
- Repaglinide: prandial glucose regulation in clinical practice.Diabetes, obesity & metabolism · 2000
- Repaglinide: a review of its use in type 2 diabetes mellitus.Drugs · 2012
- Repaglinide, a new oral antidiabetic agent: a review of recent preclinical studies.European journal of clinical investigation · 1999
- Repaglinide as monotherapy in Type 2 diabetes.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 1999
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Mass
- 452.267508
- Has use
- medication
Show 8 more facts
- chemical formula
- C₂₇H₃₆N₂O₄
- defined daily dose
- 4
- World Health Organisation international non-proprietary name
- repaglinide
- isomeric SMILES
- CCOC1=C(C=CC(=C1)CC(=O)N[C@@H](CC(C)C)C2=CC=CC=C2N3CCCCC3)C(=O)O
- canonical SMILES
- CCOC1=C(C=CC(=C1)CC(=O)NC(CC(C)C)C2=CC=CC=C2N3CCCCC3)C(=O)O
- Commons category
- Repaglinide
- subject has role
- anti-diabetic medication
- found in taxon
- Salvia regla
Sources (6)
via Wikidata · CC0
Article · 日本語
レパグリニド（Repaglinide）は、ミチグリニドやナテグリニド等と同じフェニルアラニン誘導体であり、グリニド系と呼ばれる群に属する経口糖尿病薬の一つである。1983年に発見された。膵臓のβ細胞からのインスリン分泌を促進する。日本では商品名シュアポストで、大日本住友製薬により販売されている。米国では Prandinである。
Abstract from DBpedia / Wikipedia · CC BY-SA