ribonuclease
Sign in to saveAlso known as ribonucleases
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
Key facts
- Protein family.PDB
- A:56-137 A:56-137 B:11-92 A:11-92 A:11-92 B:11-92 B:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 B:11-92 B:11-92 B:11-92 X:11-92 B:79-159 A:79-159 B:72-161 A:72-161 B:72-161 A:72-161 A:72-161 B:67-156 A:67-156 B:67-156 A:67-156 C:67-156 C:67-156 A:67-156 B:67-156 B:67-156 B:67-156 B:67-156 C:67-156 B:67-156 B:67-156 B:67-156 B:67-156 A:67-156 C:67-156 B:67-156 B:67-156 C:67-156 C:67-156 C:67-156 B:67-156 :67-156 C:67-156 :67-156 C:67-156 C:67-156 A:67-156 C:67-156 A:67-156 B:67-156 A:67-156 A:67-156 C:67-156 B:67-156 M:67-156 A:46-129 A:46-129 46-129 A:46-129 B:46-129 A:46-129 D:46-129 :46-129 46-129 :46-129 A:46-129 A:46-129 B:46-129 A:46-129 46-129 A:46-129 A:46-129 A:46-129 :46-129 D:46-129 46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 :46-129 46-129 :46-129 :46-129 B:46-129 B:46-129 :46-129 46-129 D:46-129 :46-129 46-129 A:46-129 A:46-129 46-129 :46-129 :46-129 C:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 B:46-129 :46-129 A:46-129 A:46-129 :46-129 A:46-129 :46-129 A:46-129 46-129 :46-129 :46-129 46-129 A:46-129 :46-129 46-129 :21-102 :21-102 45-127 :45-127 :45-127 45-127 :23-113 A:82-174 B:82-174 A:82-174 A:82-174 A:83-175 A:83-175
- Protein family.Symbol
- Ribonuclease
- Protein family.Name
- Ribonuclease
- Protein family.image
- 3agn.png
- Protein family.caption
- Ustilago sphaerogena Ribonuclease U2 with AMP PDB entry
- Protein family.Pfam
- PF00545
- Protein family.InterPro
- IPR000026
- Protein family.SCOP
- 1brn
via Wikipedia infobox
Research
58,937 papers- Emerging biological functions of ribonuclease 1 and angiogenin.Critical reviews in biochemistry and molecular biology · 2022
- Semisynthesis of Human Ribonuclease-S.Bioconjugate chemistry · 2021
- Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity.Current pharmaceutical biotechnology · 2008
- A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense.International journal of molecular sciences · 2016
- Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid.Chembiochem : a European journal of chemical biology · 2022
via PubMed
~8 min read
Encyclopedic overview
9 sectionsContents
- Function
- Classification
- Major types of endoribonucleases
- Major types of exoribonucleases
- RNase specificity
- RNase contamination during RNA extraction
- References
- Sources
- External links
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
== Function == Ribonucleases are found in all domains of life as well as in viruses. While some families of RNases, such as EndoU-like RNases, are ubiquitous, others, such as RNase A, are only found in a subset of vertebrates. RNases play a role in a multitude of processes including antiviral defense, mRNA regulation, RNA maturation of coding and noncoding RNA, RNA interference and replication in retroviruses.
Excerpted from Wikipedia’s “ribonuclease” article, available under the CC BY-SA 4.0 licence.