ribonuclease
Sign in to saveRibonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
Key facts
- Protein family.PDB
- A:56-137 A:56-137 B:11-92 A:11-92 A:11-92 B:11-92 B:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 A:11-92 A:11-92 B:11-92 B:11-92 B:11-92 B:11-92 X:11-92 B:79-159 A:79-159 B:72-161 A:72-161 B:72-161 A:72-161 A:72-161 B:67-156 A:67-156 B:67-156 A:67-156 C:67-156 C:67-156 A:67-156 B:67-156 B:67-156 B:67-156 B:67-156 C:67-156 B:67-156 B:67-156 B:67-156 B:67-156 A:67-156 C:67-156 B:67-156 B:67-156 C:67-156 C:67-156 C:67-156 B:67-156 :67-156 C:67-156 :67-156 C:67-156 C:67-156 A:67-156 C:67-156 A:67-156 B:67-156 A:67-156 A:67-156 C:67-156 B:67-156 M:67-156 A:46-129 A:46-129 46-129 A:46-129 B:46-129 A:46-129 D:46-129 :46-129 46-129 :46-129 A:46-129 A:46-129 B:46-129 A:46-129 46-129 A:46-129 A:46-129 A:46-129 :46-129 D:46-129 46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 :46-129 46-129 :46-129 :46-129 B:46-129 B:46-129 :46-129 46-129 D:46-129 :46-129 46-129 A:46-129 A:46-129 46-129 :46-129 :46-129 C:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 A:46-129 B:46-129 :46-129 A:46-129 A:46-129 :46-129 A:46-129 :46-129 A:46-129 46-129 :46-129 :46-129 46-129 A:46-129 :46-129 46-129 :21-102 :21-102 45-127 :45-127 :45-127 45-127 :23-113 A:82-174 B:82-174 A:82-174 A:82-174 A:83-175 A:83-175
- Protein family.Symbol
- Ribonuclease
- Protein family.Name
- Ribonuclease
- Protein family.image
- 3agn.png
- Protein family.caption
- Ustilago sphaerogena Ribonuclease U2 with AMP PDB entry
- Protein family.Pfam
- PF00545
- Protein family.InterPro
- IPR000026
- Protein family.SCOP
- 1brn
via Wikipedia infobox
Research
58,937 papers- Emerging biological functions of ribonuclease 1 and angiogenin.Critical reviews in biochemistry and molecular biology · 2022
- Semisynthesis of Human Ribonuclease-S.Bioconjugate chemistry · 2021
- Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity.Current pharmaceutical biotechnology · 2008
- A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense.International journal of molecular sciences · 2016
- Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid.Chembiochem : a European journal of chemical biology · 2022
via PubMed
Article
9 sectionsContents
- Function
- Classification
- Major types of endoribonucleases
- Major types of exoribonucleases
- RNase specificity
- RNase contamination during RNA extraction
- References
- Sources
- External links
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
== Function == Ribonucleases are found in all domains of life as well as in viruses. While some families of RNases, such as EndoU-like RNases, are ubiquitous, others, such as RNase A, are only found in a subset of vertebrates. RNases play a role in a multitude of processes including antiviral defense, mRNA regulation, RNA maturation of coding and noncoding RNA, RNA interference and replication in retroviruses.