RNASEH1
Sign in to saveAlso known as H1RNA, RNH1, PEOB2, ribonuclease H1
Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.
Gene data
RNASEH1- Name
- ribonuclease H1
- Type
- protein-coding
- Aliases
- H1RNA, PEOB2, RNH1
This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017].
via MyGene.info
Gene · Ensembl
ribonuclease H1
- Symbol
- RNASEH1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:3,541,430-3,558,371
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 2qk9 EBI.png
Show 8 more facts
- exact match
- identifiers.org/ncbigene/246243
- HomoloGene ID
- 2202
- chromosome
- human chromosome 2
- found in taxon
- Homo sapiens
- genomic start
- 3541430
- genomic end
- 3558333
- cytogenetic location
- 2p25.3
- expressed in
- gonad
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.
==References==
Excerpted from Wikipedia’s “RNASEH1” article, available under the CC BY-SA 4.0 licence.