EntityQ7376558· pop 11· linked from 283 articles

rucaparib

Rucaparib, sold under the brand name Rubraca, is a PARP inhibitor used as an anti-cancer agent. Rucaparib is a first-in-class pharmaceutical drug targeting the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It is taken by mouth.

Key facts

Drug.image: Rucaparib.svg
Drug.image_class: skin-invert-image
Drug.caption: Above: molecular structure of rucaparib Below: 3D representation of a rucaparib molecule
Drug.image2: Rucaparib 3D.png
Drug.image_class2: bg-transparent
Drug.tradename: Rubraca
Drug.MedlinePlus: a617002
Drug.DailyMedID: Rucaparib
Drug.pregnancy_category: Not recommended
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: L01
Drug.ATC_suffix: XK03
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.legal_status: Rx-only
Drug.bioavailability: 30–45% (Tmax = 1.9 hours)
Drug.protein_bound: 70% (in vitro)

via Wikipedia infobox

Chemical data

Formula: C19H18FN3O
Molecular weight: 323.4 g/mol
IUPAC name: 6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one

via PubChem

Wikidata facts

Subclass of: chemical compound
Mass: +323.143

Show 3 more facts

P2868: PARP inhibitor
P129: Poly(ADP-ribose) polymerase 1
P366: medication

via Wikidata · CC0

Article

10 sections

Contents

Medical uses
Pharmacology
Mechanism of action
History
Society and culture
Legal status
Research
Clinical trials
References
External links

{{Infobox drug | image = Rucaparib.svg | image_class = skin-invert-image | alt = | caption = Above: molecular structure of rucaparib Below: 3D representation of a rucaparib molecule | image2 = Rucaparib 3D.png | image_class2 = bg-transparent | alt2 =