SCN1B
Sign in to saveAlso known as ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1, EIEE52, DEE52
Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.
In the Vinony graph
Within Vinony's link graph, SCN1B is referenced by 360 other articles, and connects out to PubMed, Ensembl genome database project and water.
It is catalogued under topics including Genes on human chromosome 19 and Sodium channels.
Its subject is documented across 4 Wikipedia language editions.
Gene data
SCN1B- Name
- sodium voltage-gated channel beta subunit 1
- Type
- protein-coding
- Position
- 35,030,444–35,040,455 (+)
- Aliases
- ATFB13, BRGDA5, DEE52, EIEE52, GEFSP1
- Ensembl
- ENSG00000105711
- RefSeq RNA
- NM_001037.5, NM_001321605.2, NM_199037.5
- RefSeq protein
- NP_001028.1, NP_001308534.1, NP_950238.1
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sodium voltage-gated channel beta subunit 1
- Symbol
- SCN1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:35,030,444-35,040,455
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 810
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6324
- genomic end
- 35040449
- genomic start
- 35030470
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.11
- expressed in
- prefrontal cortex
- Commons category
- SCN1B
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Clinical significance
- See also
- References
- Further reading
- External links
Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.
Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM]
Excerpted from Wikipedia’s “SCN1B” article, available under the CC BY-SA 4.0 licence.