SCNN1D
Sign in to saveAlso known as ENaCd, ENaCdelta, SCNED, dNaCh, sodium channel epithelial 1 delta subunit, sodium channel epithelial 1 subunit delta
The SCNN1D gene encodes for the δ (delta) subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1G.
Gene data
SCNN1D- Name
- sodium channel epithelial 1 subunit delta
- Type
- protein-coding
- Aliases
- ENaCd, ENaCdelta, SCNED, dNaCh
Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
sodium channel epithelial 1 subunit delta
- Symbol
- SCNN1D
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:1,280,436-1,292,029
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 48152
- exact match
- identifiers.org/ncbigene/6339
- genomic end
- 1227409
- genomic start
- 1215816
- cytogenetic location
- 1p36.33
Sources (3)
via Wikidata · CC0
~5 min read
Article
9 sectionsContents
- History
- Gene structure
- Tissue-specific expression
- Protein structure
- Associated diseases
- Notes
- References
- Further reading
- External links
The SCNN1D gene encodes for the δ (delta) subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1B, and SCNN1G.
ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1D) represents that these are NON-voltage-gated channels.