Setrobuvir (also known as ANA-598) was an experimental drug candidate for the treatment of hepatitis C that was discovered at Anadys Pharmaceuticals, which was acquired by Roche in 2011; Roche terminated development in July 2015. It was in Phase IIb clinical trials, used in combination with interferon and ribavirin, targeting hepatitis C patients with genotype 1.
{{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 461749550 | Reference = | ImageFile = Setrobuvir.svg | ImageClass = skin-invert-image | ImageSize = 200px | ImageAlt = | PIN = N-(3-{(4aR,5S,8R,8aS)-1-[(4-Fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2,4a,5,6,7,8,8a-octahydro-5,8-methanoquinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6,2,4-benzothiadiazin-7-yl)methanesulfonamide | OtherNames = ANA-598; ANA598
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).