SGCB
Sign in to saveAlso known as A3b, LGMD2E, SGC, sarcoglycan beta, LGMDR4
Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.
In the Vinony graph
Vinony's link graph records 76 inbound references to SGCB, and connects out to skeletal muscle, PubMed and myocardium.
It is catalogued under the topic Genes on human chromosome 4.
Vinony links it to 6 Wikipedia language editions.
Gene data
SGCB- Name
- sarcoglycan beta
- Type
- protein-coding
- Position
- 52,020,697–52,038,305 (−)
- Aliases
- A3b, LGMD2E, LGMDR4, SGC
- Ensembl
- ENSG00000163069
- RefSeq RNA
- NM_000232.5, NM_001440519.1, NM_001440520.1, XM_047416076.1, XM_054350716.1
- RefSeq protein
- NP_000223.1, NP_001427448.1, NP_001427449.1, XP_047272032.1, XP_054206691.1
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008].
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sarcoglycan beta
- Symbol
- SGCB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:52,020,697-52,038,305
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 195
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6443
- genomic end
- 52038299
- genomic start
- 52886872
- chromosome
- human chromosome 4
- cytogenetic location
- 4q12
- expressed in
- tibia
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Clinical significance
- References
- Further reading
- External links
Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.
The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD; MIM 300377) and syntrophin (SNTA1; MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA; MIM 600119) (Crosbie et al., 2000).[supplied by OMIM].
Excerpted from Wikipedia’s “SGCB” article, available under the CC BY-SA 4.0 licence.