Structure via PubChem · Public domain (PubChem)
sabcomeline
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Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results.
Chemical data
- Formula
- C10H15N3O
- Molecular weight
- 193.25 g/mol
- IUPAC name
- (3Z,3R)-N-methoxy-1-azabicyclo[2.2.2]octane-3-carboximidoyl cyanide
- SMILES
- CO/N=C(\C#N)/[C@H]1CN2CCC1CC2
- InChIKey
- IQWCBYSUUOFOMF-QTLFRQQHSA-N
- XLogP
- 1
- Polar surface area
- 48.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 193.121512
Show 4 more facts
- chemical formula
- C₁₀H₁₅N₃O
- isomeric SMILES
- CO/N=C(\C#N)/[C@H]1CN2CCC1CC2
- canonical SMILES
- CON=C(C#N)C1CN2CCC1CC2
- Commons category
- Sabcomeline
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results.
It is a non-selective agonist of all five muscarinic acetylcholine receptors with similar affinities. However, functional selectivity for the M1 receptor has been claimed in vitro and in vivo.
Excerpted from Wikipedia’s “sabcomeline” article, available under the CC BY-SA 4.0 licence.