SHC1

Also known as SHC, SHCA, SHC adaptor protein 1

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

Gene data

SHC1

Name: SHC adaptor protein 1
Type: protein-coding
Position: 154,962,284–154,974,395 (−)
Aliases: SHC, SHCA
Ensembl: ENSG00000160691
RefSeq RNA: NM_001130040.2, NM_001130041.2, NM_001202859.2, NM_003029.5, NM_183001.5
RefSeq protein: NP_001123512.1, NP_001123513.1, NP_001189788.1, NP_003020.2, NP_892113.4

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

Pathways

ErbB signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Focal adhesion - Homo sapiens (human)Natural killer cell mediated cytotoxicity - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)Estrogen signaling pathway - Homo sapiens (human)Prolactin signaling pathway - Homo sapiens (human)

via MyGene.info

Wikidata facts

Image: Protein SHC1 PDB 1mil.png

Show 6 more facts

HomoloGene ID: 7934
exact match: identifiers.org/ncbigene/6464
genomic end: 154946871
genomic start: 154934774
cytogenetic location: 1q21.3
Commons category: SHC1

Sources (4)

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~6 min read

Article

10 sections

Contents

Gene and expression
Function
EGFR pathway
MCT-1 regulation
Oxidative stress
Life span
p66SHC metabolism
Clinical significance
References
Further reading

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

SCOP classifies the 3D structure as belonging to the SH2 domain family.