SIN3B
Sign in to saveAlso known as Paired amphipathic helix protein Sin3b, SIN3 transcription regulator family member B
gene umano
Gene data
SIN3B- Name
- SIN3 transcription regulator family member B
- Type
- protein-coding
- Position
- 16,829,387–16,880,355 (+)
- Ensembl
- ENSG00000127511
- RefSeq RNA
- NM_001297595.2, NM_001297597.2, NM_015260.4, XM_006722704.2, XM_054320368.1
- RefSeq protein
- NP_001284524.1, NP_001284526.1, NP_056075.1, XP_006722767.1, XP_054176343.1
Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription by RNA polymerase II; and striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIregulation of DNA-templated transcriptionnegative regulation of cell migrationnegative regulation of DNA-templated transcriptionnegative regulation of transcription initiation by RNA polymerase IInegative regulation of transcription initiation by RNA polymerase II
Molecular function
Cellular component
Pathways
MetabolismEpigenetic regulation of gene expressionGeneric Transcription PathwayCellular responses to stressRegulation of lipid metabolism by PPARalphaNoRC negatively regulates rRNA expressionNegative epigenetic regulation of rRNA expressionMetabolism of lipidsRNA Polymerase II TranscriptionGene expression (Transcription)
via MyGene.info
Gene · Ensembl
SIN3 transcription regulator family member B
- Symbol
- SIN3B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:16,829,387-16,880,355
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Research
122 papers- SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
- Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma.Pharmacological research · 2025
- The potential of targeting Sin3B and its associated complexes for cancer therapy.Expert opinion on therapeutic targets · 2017
- SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma.Journal of molecular cell biology · 2019
- Chromatin-Associated SIN3B Protects Cancer Cells from Genotoxic Stress-Induced Apoptosis and Dictates DNA Damage Repair Pathway Choice.Molecular cancer research : MCR · 2023
via PubMed
Wikidata facts
- Instance of
- gene
- Image
- Protein SIN3B PDB 1e91.png
Show 8 more facts
- HomoloGene ID
- 81810
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23309
- genomic end
- 16991164
- genomic start
- 16829398
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.11
- expressed in
- sural nerve
Sources (4)
via Wikidata · CC0