suxibuzone
Sign in to saveAlso known as 4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate, 4-Hydroxymethylbutazolidine hemisuccinate
Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone, and is commonly used in horses.
Research
26 papers- The disposition of suxibuzone in the horse.Journal of veterinary pharmacology and therapeutics · 1993
- Unveiling the Potential of a New β-Cyclodextrin-Suxibuzone Conjugate in Proteasome Regulation.ChemMedChem · 2025
- Promotion of hepatocarcinogenesis by suxibuzone in rats initiated with 3'-methyl-4-dimethylaminoazobenzene.Cancer letters · 1987
- Pharmacokinetics and bioequivalence of two suxibuzone oral dosage forms in horses.Journal of veterinary pharmacology and therapeutics · 1999
- Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses.Veterinary therapeutics : research in applied veterinary medicine · 2009
via PubMed
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Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone, and is commonly used in horses.
==Synthesis== Suxibuzone is synthesized by the following method: class=skin-invert-image|center|500px Phenylbutazone [50-33-9] (1) is hydroxymethylated with formaldehyde giving ~86% 4-butyl-4-(hydroxymethyl)-1,2-diphenylpyrazolidine-3,5-dione [23111-33-3] (2). This is then esterified with succinic anhydride. [108-30-5] (3) to give (4).
Excerpted from Wikipedia’s “suxibuzone” article, available under the CC BY-SA 4.0 licence.