tenocyclidine
Sign in to saveAlso known as TCP, 1-[1-(thiophen-2-yl)cyclohexyl]piperidine, thienyl cyclohexylpiperidine
Tenocyclidine (TCP) is a dissociative anesthetic with psychostimulant effects. It was discovered by a team at Parke-Davis in the late 1950s. It is similar in effects to phencyclidine (PCP) but is considerably more potent. TCP has slightly different binding properties to PCP, with more affinity for the NMDA receptors, but less affinity for the sigma receptors. Because of its high affinity for the PCP site of the NMDA receptor complex, the 3H radiolabelled form of TCP is widely used in research into NMDA receptors.
Research
276 papers- Drug repurposing with network reinforcement.BMC bioinformatics · 2019
- Tenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection.Acta biochimica Polonica · 2008
- In vitro biological efficiency of tenocyclidine-TCP and its adamantane derivative TAMORF.Toxicology in vitro : an international journal published in association with BIBRA · 2006
- A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.The Journal of biological chemistry · 2019
- Adamantyl tenocyclidines--adjuvant therapy in poisoning with organophosphorus compounds and carbamates.Archives of toxicology · 2002
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Encyclopedic overview
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Tenocyclidine (TCP) is a dissociative anesthetic with psychostimulant effects. It was discovered by a team at Parke-Davis in the late 1950s. It is similar in effects to phencyclidine (PCP) but is considerably more potent. TCP has slightly different binding properties to PCP, with more affinity for the NMDA receptors, but less affinity for the sigma receptors. Because of its high affinity for the PCP site of the NMDA receptor complex, the 3H radiolabelled form of TCP is widely used in research into NMDA receptors.
TCP acts primarily as an NMDA receptor antagonist which blocks the activity of the NMDA receptor, however its increased psychostimulant effects compared to PCP suggests it also has relatively greater activity as a dopamine reuptake inhibitor (DRI). Due to its similarity in effects to PCP, TCP was placed into the Schedule I list of illegal drugs in the 1970s, although it was only briefly used in the 1970s and 1980s and is now little known.
Excerpted from Wikipedia’s “tenocyclidine” article, available under the CC BY-SA 4.0 licence.