Structure via PubChem · Public domain (PubChem)
tepotinib
Sign in to saveAlso known as compound 22 [PMID: 25736998], EMD 1214063, EMD-1214063, MSC2156119, MSC2156119J
Tepotinib, sold under the brand name Tepmetko, is an anti-cancer medication used for the treatment of adults with non-small cell lung cancer (NSCLC).
In the Vinony graph
Vinony's link graph records 215 inbound references to tepotinib, and connects out to VEGF receptors, MET proto-oncogene, receptor tyrosine kinase and diarrhea.
It sits within the topics Antineoplastic drugs, Chemicals using indexlabels and Drugs with non-standard legal status.
Vinony links it to 7 Wikipedia language editions.
Chemical data
- Formula
- C29H28N6O2
- Molecular weight
- 492.6 g/mol
- IUPAC name
- 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- SMILES
- CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N
- InChIKey
- AHYMHWXQRWRBKT-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 94.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- non-small cell lung carcinoma, hepatocellular carcinoma, liver disease, neoplasm
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 492.227
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₉H₂₈N₆O₂
- canonical SMILES
- CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC(=CC=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N
- physically interacts with
- MET proto-oncogene, receptor tyrosine kinase
- Commons category
- Tepotinib
- subject has role
- protein kinase inhibitors
- medical condition treated
- non-small-cell lung carcinoma
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Adverse effects
- Society and culture
- Legal status
- References
- Further reading
- External links
{{Infobox drug | image = Tepotinib.svg | image_class = skin-invert-image | width = | alt = | caption = | image2 = Tepotinib ball-and-stick 4R1V.png | image_class2 = bg-transparent | alt2 =
| pronounce = | tradename = Tepmetko | Drugs.com = | MedlinePlus = a621012 | DailyMedID = Tepotinib | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= Not recommended | routes_of_administration = By mouth | class = | ATC_prefix = L01 | ATC_suffix = EP02 | ATC_supplemental =
Excerpted from Wikipedia’s “tepotinib” article, available under the CC BY-SA 4.0 licence.