TGIF2

Also known as TGFB induced factor homeobox 2

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to TGIF2, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 20.

Vinony links it to 6 Wikipedia language editions.

Gene data

TGIF2

Name: TGFB induced factor homeobox 2
Type: protein-coding
Position: 36,571,894–36,593,950 (+)
Ensembl: ENSG00000118707
RefSeq RNA: NM_001199513.2, NM_001199514.2, NM_001199515.2, NM_021809.7
RefSeq protein: NP_001186442.1, NP_001186443.1, NP_001186444.1, NP_068581.1

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of DNA-templated transcription

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

TGF-beta signaling pathway - Homo sapiens (human)Cell-Cell communication Signal Transduction Signaling by TGF-beta Receptor Complex Generic Transcription Pathway Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Adherens junctions interactions Cell-cell junction organization

via MyGene.info

Gene · Ensembl

TGFB induced factor homeobox 2

Symbol: TGIF2
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:36,571,894-36,593,950
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 32514
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/60436
genomic end: 35222353
genomic start: 35201891
chromosome: human chromosome 20
cytogenetic location: 20q11.23
expressed in: monocyte

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.

Excerpted from Wikipedia’s “TGIF2” article, available under the CC BY-SA 4.0 licence.