TGIF2
Sign in to saveAlso known as TGFB induced factor homeobox 2
Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.
Gene data
TGIF2- Name
- TGFB induced factor homeobox 2
- Type
- protein-coding
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 32514
- exact match
- identifiers.org/ncbigene/60436
- genomic end
- 35222353
- genomic start
- 35201891
- cytogenetic location
- 20q11.23
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Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.