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تالیدومید

File:Thalidomide_enantiomers.svg · Wikimedia Commons · See Wikimedia Commons

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تالیدومید

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Also known as K-17, 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, N-(2,6-dioxo-3-piperidyl)phthalimide, (±)-thalidomide, 3-Phthalimidoglutarimide, N-Phthalyl-glutaminsaeure-imid, Talidomida, Thalidomidum

Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions). Thalidomide has been used to treat conditions associated with HIV: aphthous ulcers, HIV-associated wasting syndrome, diarrhea, and Kaposi's sarcoma, but increases in HIV viral load have been reported.

AI overview

Thalidomide is a medication taken by mouth that is used today to treat various cancers, graft-versus-host disease, skin conditions, and certain HIV-related problems. It matters because it is an effective treatment option for several serious medical conditions, though it has been associated with some complications in certain uses, such as increases in HIV viral load in some patients.

AI-generated from the Wikipedia summary — may contain errors.

Key facts

Drug.Watchedfields
changed
Drug.Verifiedfields
changed
Drug.verifiedrevid
420478187
Drug.image
Thalidomide enantiomers.svg
Drug.image_class
skin-invert-image
Drug.width
200
Drug.chirality
Racemic mixture
Drug.tradename
Contergan, Thalomid, others
Drug.MedlinePlus
a699032
Drug.licence_EU
yes
Drug.DailyMedID
Thalidomide
Drug.licence_US
Thalidomide
Drug.pregnancy_AU
X
Drug.routes_of_administration
By mouth
Drug.ATC_prefix
L04
Drug.ATC_suffix
AX02
Drug.legal_AU
S4
Drug.legal_BR
C3

via Wikipedia infobox

Chemical data

Formula
C13H10N2O4
Molecular weight
258.23 g/mol
IUPAC name
2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChIKey
UEJJHQNACJXSKW-UHFFFAOYSA-N
XLogP
0.3
Polar surface area
83.6 Ų
H-bond donors
1
H-bond acceptors
4
Formal charge
0

via PubChem

Gallery (20)