沙利度胺

Also known as K-17, 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, N-(2,6-dioxo-3-piperidyl)phthalimide, (±)-thalidomide, 3-Phthalimidoglutarimide, N-Phthalyl-glutaminsaeure-imid, Talidomida, Thalidomidum

化合物

AI overview

Thalidomide is a medication taken by mouth that is used today to treat various cancers, graft-versus-host disease, skin conditions, and certain HIV-related problems. It matters because it is an effective treatment option for several serious medical conditions, though it has been associated with some complications in certain uses, such as increases in HIV viral load in some patients.

AI-generated from the Wikipedia summary — may contain errors.

Key facts

Drug.Watchedfields: changed
Drug.Verifiedfields: changed
Drug.verifiedrevid: 420478187
Drug.image: Thalidomide enantiomers.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.chirality: Racemic mixture
Drug.tradename: Contergan, Thalomid, others
Drug.MedlinePlus: a699032
Drug.licence_EU: yes
Drug.DailyMedID: Thalidomide
Drug.licence_US: Thalidomide
Drug.pregnancy_AU: X
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: L04
Drug.ATC_suffix: AX02
Drug.legal_AU: S4
Drug.legal_BR: C3

via Wikipedia infobox

Chemical data

Formula: C13H10N2O4
Molecular weight: 258.23 g/mol
IUPAC name: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChIKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
XLogP: 0.3
Polar surface area: 83.6 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1956
Admin. routes: oral
Indications: immune system disease, Crohn's disease, systemic scleroderma, sarcoma

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Has part: carbon
Mass: 258.064057
Has use: medication

Show 11 more facts

Commons category: Thalidomide
chemical formula: C₁₃H₁₀N₂O₄
medical condition treated: multiple myeloma
World Health Organisation international non-proprietary name: thalidomide
canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
defined daily dose: 0.1
MCN code: 2925.19.10
native label: Thalidomide
route of administration: oral administration
has effect: Phocomelia due to thalidomide
physically interacts with: Cereblon

Sources (12)

via Wikidata · CC0

Article · 中文

沙利度胺（英語：Thalidomide）又名反应停、酞咪脈啶酮、沙利竇邁、賽得（Thado），是研制抗菌药物过程中发现的一种具有中枢抑制作用的药物。曾经作为抗妊娠嘔吐反应药物在欧洲和日本被广泛使用，投入使用后不久，数据显示使用该药物的孕妇的流产率和海豹肢症（Phocomelia）畸胎率上升，致使该药物退出市场，该事件被称为反应停事件。后来研究发现该药物有两种光學异构体，其中的R构型是安全的，而S构型有致畸型作用，兩種構型可在人體內轉換。但此前科学界没有意识到两种构型在人体内有不同的生理活性。最近，科学家经过研究发现沙利度胺对于人體免疫系统有调节作用，可以治疗红斑狼疮；此外沙利度胺还可以用于癌症的治疗，目前对沙利度胺的这些治疗作用正处于临床研究阶段。

Abstract from DBpedia / Wikipedia · CC BY-SA