talidomid

Also known as K-17, 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, N-(2,6-dioxo-3-piperidyl)phthalimide, (±)-thalidomide, 3-Phthalimidoglutarimide, N-Phthalyl-glutaminsaeure-imid, Talidomida, Thalidomidum

związek chemiczny

AI overview

Thalidomide is a medication taken by mouth that is used today to treat various cancers, graft-versus-host disease, skin conditions, and certain HIV-related problems. It matters because it is an effective treatment option for several serious medical conditions, though it has been associated with some complications in certain uses, such as increases in HIV viral load in some patients.

AI-generated from the Wikipedia summary — may contain errors.

In the Vinony graph

Within Vinony's link graph, talidomid is referenced by 1,091 other articles, and connects out to United States Food and Drug Administration, teratology and angiogenesis inhibitor.

It is catalogued under topics including 20th-century health disasters, Antileprotic drugs and Causes of amputation.

Its subject is documented across 52 Wikipedia language editions.

Key facts

Drug.Watchedfields: changed
Drug.Verifiedfields: changed
Drug.verifiedrevid: 420478187
Drug.image: Thalidomide enantiomers.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.chirality: Racemic mixture
Drug.tradename: Contergan, Thalomid, others
Drug.MedlinePlus: a699032
Drug.licence_EU: yes
Drug.DailyMedID: Thalidomide
Drug.licence_US: Thalidomide
Drug.pregnancy_AU: X
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: L04
Drug.ATC_suffix: AX02
Drug.legal_AU: S4
Drug.legal_BR: C3

via Wikipedia infobox

Chemical data

Formula: C13H10N2O4
Molecular weight: 258.23 g/mol
IUPAC name: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChIKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
XLogP: 0.3
Polar surface area: 83.6 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1956
Admin. routes: oral
Indications: immune system disease, Crohn's disease, systemic scleroderma, sarcoma

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Has part: carbon
Mass: 258.064057
Has use: medication

Show 11 more facts

Commons category: Thalidomide
chemical formula: C₁₃H₁₀N₂O₄
medical condition treated: multiple myeloma
World Health Organisation international non-proprietary name: thalidomide
canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
defined daily dose: 0.1
MCN code: 2925.19.10
native label: Thalidomide
route of administration: oral administration
has effect: Phocomelia due to thalidomide
physically interacts with: Cereblon

Sources (12)

via Wikidata · CC0

Article · Polski

Talidomid – organiczny związek chemiczny zbudowany z reszty ftalimidowej i , stosowany jako lek o działaniu przeciwwymiotnym, przeciwbólowym, usypiającym i hipnotycznym. Talidomid został uzyskany przez chemików z Chemie Grünenthal z Republiki Federalnej Niemiec w 1953 roku.

Abstract from DBpedia / Wikipedia · CC BY-SA