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thalidomide · Vinony

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20th-century health disasters
thalidomide

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File:Thalidomide_enantiomers.svg · Wikimedia Commons · See Wikimedia Commons

EntityQ203174· pop 54· linked from 1,091 articles

thalidomide

Also known as K-17, 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, N-(2,6-dioxo-3-piperidyl)phthalimide, (±)-thalidomide, 3-Phthalimidoglutarimide, N-Phthalyl-glutaminsaeure-imid, Talidomida, Thalidomidum

AI overview

Thalidomide is a medication taken by mouth that is used today to treat various cancers, graft-versus-host disease, skin conditions, and certain HIV-related problems. It matters because it is an effective treatment option for several serious medical conditions, though it has been associated with some complications in certain uses, such as increases in HIV viral load in some patients.

AI-generated from the Wikipedia summary — may contain errors.

Key facts

Drug.Watchedfields: changed
Drug.Verifiedfields: changed
Drug.verifiedrevid: 420478187
Drug.image: Thalidomide enantiomers.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.chirality: Racemic mixture
Drug.tradename: Contergan, Thalomid, others
Drug.MedlinePlus: a699032
Drug.licence_EU: yes
Drug.DailyMedID: Thalidomide
Drug.licence_US: Thalidomide
Drug.pregnancy_AU

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Connections

United States Food and Drug Administration

Categories

20th-century health disasters Antileprotic drugs Causes of amputation Cereblon E3 ligase modulators Chirality Congenital amputations Drugboxes which contain changes to verified fields Drugboxes which contain changes to watched fields Drug has EMA link Drug safety Drugs developed by Bristol Myers Squibb Drugs with non-standard legal status

Sources

wikipedia.extlinksexternal_links
wikipedia.refscitation
wikipedia.externallinksexternallink

Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions). Thalidomide has been used to treat conditions associated with HIV: aphthous ulcers, HIV-associated wasting syndrome, diarrhea, and Kaposi's sarcoma, but increases in HIV viral load have been reported.

X

Drug.routes_of_administration

By mouth

Drug.ATC_prefix

L04

Drug.ATC_suffix

AX02

Drug.legal_AU

S4

Drug.legal_BR

C3

via Wikipedia infobox

Chemical data

Formula: C13H10N2O4
Molecular weight: 258.23 g/mol
IUPAC name: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChIKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
XLogP: 0.3
Polar surface area: 83.6 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Wikidata facts

Mass: 258.064057

Show 7 more facts

Commons category: Thalidomide
chemical formula: C₁₃H₁₀N₂O₄
World Health Organisation international non-proprietary name: thalidomide
canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
defined daily dose: 0.1
MCN code: 2925.19.10
native label: Thalidomide

Sources (12)

wikidata.org
commonchemistry.cas.org
drugs.ncats.io
accessdata.fda.gov
guidetopharmacology.org
whocc.no
oehha.ca.gov
ncbi.nlm.nih.gov
ru.wikipedia.org
docs.openalex.org
web.archive.org
platform.opentargets.org

via Wikidata · CC0

Bahasa Indonesia

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via Wikidata sitelinks · CC0

angiogenesis inhibitor

Entity

aphthous stomatitis

peripheral neuropathy

oral administration

erythema nodosum

abiraterone acetate

regulation of therapeutic goods

interferon type I

World Health Organization

ECHA InfoCard ID from Wikidata

German inventions

Health disasters in the United Kingdom

Immunosuppressants

Medical controversies

Medical scandals

Medical scandals in the Republic of Ireland

Nonsteroidal antiandrogens

Products introduced in 1957

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