TRIM25
Sign in to saveAlso known as EFP, RNF147, Z147, ZNF147, tripartite motif containing 25
Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.
In the Vinony graph
Vinony's link graph records 13 inbound references to TRIM25, and connects out to PubMed, ubiquitin and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Vinony links it to 5 Wikipedia language editions.
Gene data
TRIM25- Name
- tripartite motif containing 25
- Type
- protein-coding
- Position
- 56,836,387–56,914,080 (−)
- Aliases
- EFP, RNF147, Z147, ZNF147
- Ensembl
- ENSG00000121060
- RefSeq RNA
- NM_005082.5
- RefSeq protein
- NP_005073.2
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tripartite motif containing 25
- Symbol
- TRIM25
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:56,836,387-56,914,080
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 48325
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7706
- genomic end
- 56914080
- genomic start
- 56836387
- chromosome
- human chromosome 17
- cytogenetic location
- 17q22
- expressed in
- spleen
Sources (4)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Function
- Viral escape
- References
- Further reading
Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family grouping more than 70 TRIMs. TRIM proteins primarily function as ubiquitin ligases that regulate the innate response to infection. TRIM25 localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
Excerpted from Wikipedia’s “TRIM25” article, available under the CC BY-SA 4.0 licence.