TRIM25
Sign in to saveAlso known as EFP, RNF147, Z147, ZNF147, tripartite motif containing 25
Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.
Gene data
TRIM25- Name
- tripartite motif containing 25
- Type
- protein-coding
- Aliases
- EFP, RNF147, Z147, ZNF147
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 48325
- exact match
- identifiers.org/ncbigene/7706
- genomic end
- 56914080
- genomic start
- 56836387
- cytogenetic location
- 17q22
Sources (4)
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Structure
- Function
- Viral escape
- References
- Further reading
Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family grouping more than 70 TRIMs. TRIM proteins primarily function as ubiquitin ligases that regulate the innate response to infection. TRIM25 localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.