utrophin
Sign in to saveAlso known as DRP-1, dystrophin-related protein 1, UTRN
Utrophin is a protein that in humans is encoded by the UTRN gene. The name is a short form for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6.
Protein · UniProt
Utrophin
- Gene
- UTRN
- Organism
- Homo sapiens (Human)
- Length
- 3,433 aa
- Molecular mass
- 394,466 Da
- Evidence
- 1: Evidence at protein level
May play a role in anchoring the cytoskeleton to the plasma membrane
3D-structureActin-bindingAlternative promoter usageCalciumCell membraneCytoplasmCytoskeletonMembrane
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
1,157 papers- Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy.Nature · 2025
- Utrophin: a structural and functional comparison to dystrophin.Brain pathology (Zurich, Switzerland) · 1996
- Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
- [Utrophin, a way to cure Duchenne muscle dystrophy].Medecine sciences : M/S · 2004
- Utrophin upregulation in Duchenne muscular dystrophy.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2005
via PubMed
Clinical Trials
1 registered- PHASE2TERMINATEDProof of Concept Study to Assess Activity and Safety of SMT C1100 (Ezutromid) in Boys With Duchenne Muscular Dystrophy (DMD)Summit Therapeutics · NCT02858362
~2 min read
Encyclopedic overview
9 sectionsContents
- Discovery
- Tissue distribution
- Structure
- Function
- Clinical significance
- See also
- References
- Further reading
- External links
Utrophin is a protein that in humans is encoded by the UTRN gene. The name is a short form for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6.
== Discovery ==
Excerpted from Wikipedia’s “utrophin” article, available under the CC BY-SA 4.0 licence.